Alpha-glycerophosphocholine, more commonly known as Alpha-GPC, is a cholinergic compound which is approximately 40% Choline by weight. It is considered the most bioavailable form of Choline and is the only form which has been directly investigated as a performance enhancer.
But let’s back up and first talk about the importance of Choline…
What’s So Good About Choline?
Choline is a vitamin-like molecule which is required for the synthesis of Acetylcholine, a neurotransmitter which fulfills a wide variety of physiological roles. It is involved in decision making, memory formation, and responsiveness to sensory stimuli (i.e. paying attention and reacting to things around you).
In addition to its involvement in various aspects of cognitive function, Acetylcholine is also directly responsible for skeletal muscle activation. Acetylcholine binds to Acetylcholine receptors in muscle cells where it allows sodium ions to enter into the muscle cell, the first step in muscle contraction.
We’ve established that Acetylcholine causes muscle to contract and that Alpha-GPC increases Acetylcholine levels more so than any other form of Choline. This relationship alone may be enough to make the inference that Alpha GPC can enhance muscle contractions, right? Well luckily we don’t have to infer anything because Alpha GPC has actually been studied directly for performance enhancement.
Alpha-GPC Increases Power Output
A study published in the Journal of the International Society of Sports Nutrition in 2008 found that Alpha GPC, when taken prior to exercise, increase power output by an average of 14% as measured by bench throws.
This study also noted an increase in exercise-induced GH secretion, but since the primary purpose of Catalyst isn’t to boost GH, that remains outside the scope of this particular article. Still, it’s an interesting effect which has been noted in earlier studiesas well.
What is particularly interesting about these results is that the subjects in this study were not new to resistance training. They all had at least two years of regular exercise under their belts!
Often times, studies use subjects who don’t regularly train and this makes the results difficult to interpret for trained lifters. Some supplements that improve performance in novice weight lifters don’t make any difference at all in trained weight lifters. However, as shown in this particular study, Alpha GPC increases power output in healthy individuals who train regularly.
Catalyst Contains More Alpha GPC Than Any Other Pre-Workout Out There!
We don’t claim to have invented or discovered this wonderful ingredient. It’s been around for a while. In fact, if you do your research, you’ll find that there are several other pre-workout supplements out there which contain Alpha-GPC. The problem is they just don’t contain enough. The effective range for Alpha GPC is 300-600mg taken at once. Most pre-workouts which contain Alpha GPC contain 150mg at most. Some contain far less!
Catalyst contains 300mg of Alpha GPC, a truly effective dose which can’t be found in any other pre-workout supplement on the market.
Why Is Alpha GPC Consistently Under-Dosed?
Simple. It’s expensive! We were actually pretty astonished at how expensive it was when we first tried to source it. But then again, it’s the most bioavailable Choline source, and the only source shown to enhance performance, so what did we expect? You get what you pay for in this industry, and Alpha-GPC is DEFINITELY worth the premium.
Our Commitment To You
Although we could have gotten away with using a lower dose (because everyone else set the bar so low), we have a standard we stick to here at Momentum Nutrition and that standard dictates that we use only effective doses of key ingredients, and nothing less. It is our view that an under-dosed ingredient might as well not be used at all.
1. Ziegenfuss, Tim, Jamie Landis, and Jennifer Hofheins. “Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise.” Journal of the International Society of Sports Nutrition 5.1 (2008): 1-2.
2. Ceda, G. P., et al. “alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects.” Hormone and metabolic research= Hormon-und Stoffwechselforschung= Hormones et metabolisme 24.3 (1992): 119-121.
I'm Matt, Founder of Momentum Nutrition and SuppWithThat.com. I've spent the better part of the last decade researching and experimenting in the areas of fitness, nutrition, and supplementation, and this is where I write it all down.