Synephrine is a molecule that occurs naturally in various Citrus fruits. Most notably, Bitter Orange, an unusual fruit that is not included in most people’s diet due it’s unpleasant taste. In other Citrus fruits, there generally isn’t enough Synephrine so the fat-loss benefits must be obtained through supplementation.
Research involving Synephrine dates back to the mid 1900’s and weight-loss implications have been hypothesized for some time, but recent research has actually confirmed these hypotheses. Synephrine is indeed an effective weight-loss supplement.
How Does Synephrine Work?
Synephrine, like Epherdine, is a beta-receptor agonist meaning it directly induces lipolysis, the breakdown of fat. Through this mechanism, Synephrine is capable of increasing the basal metabolic rate, independent of food intake.
The term “Metabolic Rate” simply refers to the amount of calories your body burns while at rest (basal meaning “base”). Keep in mind, even when your not moving you’re body is constantly burning calories to power an infinite number of internal processes and functions. You can burn additional calories by exercising, but Synephrine can actually increase the amount of calories your body burns just because.
A study published in The International Journal of Medical Sciences in 2011 compared the effects of Synephrine against a Placebo, as well as Synephrine with varying combinations of Naringin and Hesperidin.
Naringin and Hesperidin are naturally occuring molecules found in Citrus Fruits (such as Grapefruits) which have their own established fat-loss mechanisms, but this study was the first to investigate the weight-loss benefits when combined with Synephrine
The researchers seperated 50 healthy, human subjects into 5 groups (10 in each group) and gave each group one of the following protocols.
- Synephrine (50mg)
- Synephrine (50mg) + Naringin (600mg)
- Synephrine (50mg) + Narigin (600mg) + Hesperidin (100mg)
- Synephrine (50mg) + Narigin (600mg) + Hesperidin (1000mg)
Here is a graph directly from the study itself which shows the net calorie consumption of each group following the protocol.
Before we get into what these results mean, there are a few interesting things to take note of.
- The placebo group had a negative metabolic rate increase. This is because V-8 Juice (with calories) was used as the medium to deliver each protocol. In terms of study design, this is simply a way of avoiding detection and keeping the subjects in the experiment blind as to what group they’re in (placebo or control), but it also lets us know that Synephrine influences metabolic rate independent of food intake.
- More hesperidin was less effective than less Hesperidin. 50mg Synphrine, 600mg Naringin, and 1000mg Hesperidin was actually less effective than the 50mg Synephrine, 600mg Naringin, and 100mg Hesperidin, meaning too much Hesperidin diminishes the effects. This is interesting because it emphasizes the fact that more isn’t always better and there is an ideal ratio when combining these ingredients.
The results of the study indicate quite clearly that Synephrine is absolutely effective for increasing your metabolic rate. Interestingly, the increase in metabolic rate seen with Synephrine is significantly amplified by Naringin and Hesperidin.
Elsewhere, Synephrine has been shown to induce weight-loss over the long term via the same mechanism described above.
Making Sense Of The Research
If you’re confused at all by the research discussed above, here’s a simple way to look at it…
Synephrine is capable of increasing the amount ofcalories your body burns ‘just because’, independent of exercise or food intake. Research indicates that a single dose of 50mg Synephrine burns around 50 additional calories. This means that if you took 50mg of Synephrine daily, you’d burn an additional 350 calories per week.
However, combined with Naringin (600mg) and Hesperidin (100mg), Synephrine is capable of inducing a metabolic rate increase of around 180 calories. This means that if you utilize this combination on a daily basis, you’d be burning an additional 1260 calories per week. Considering that you need to burn about 3500 calories to lose a pound of fat, 1260 a week is actually pretty remarkable.
Synephrine is generally dosed anywhere from 20-50mg and research indicates this is a perfectly safe range. However, if you really want to maximize the fat-loss effects of Synephrine, you should stack it with Naringin and Hesperidin at doses of:
- 50mg Synephrine
- 600mg Naringin
- 100 Hesperidin
To save you the trouble of mixing those ingredients, however, we used that precise combination in our fat-burner, Formula 56 which also contains several other research-validated, clinically dosed fat-burning ingredients.
Will SYNEPHRINE trigger false positives?
One of the primary concerns around Ephedrine is that it has been known to trigger false positives for amphetamines on drug tests for athletes. Naturally, Synephrine is has been questioned as well becuase it is a chemical relative to Ephedrine. Fortunately, there has actually been some research to investigate these concerns and Synephrine has failed to trigger false positives.
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- Jordan, Roy, et al. “β‐Adrenergic activities of octopamine and synephrine stereoisomers on guinea‐pig atria and trachea.” Journal of pharmacy and pharmacology 39.9 (1987): 752-754.
I'm Matt, Founder of Momentum Nutrition and SuppWithThat.com. I've spent the better part of the last decade researching and experimenting in the areas of fitness, nutrition, and supplementation, and this is where I write it all down.